Cisatracurium besylate(Synonyms: 顺苯磺酸阿曲库铵; 51W89)

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Cisatracurium besylate (Synonyms: 顺苯磺酸阿曲库铵; 51W89) 纯度: ≥98.0%

Cisatracurium besylate (51W89) 是非去极化神经肌肉阻断剂，能通过抑制神经肌肉的传递拮抗乙酰胆碱的效用。

Cisatracurium besylate(Synonyms: 顺苯磺酸阿曲库铵; 51W89)

Cisatracurium besylate Chemical Structure

CAS No. : 96946-42-8

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10 mM * 1 mL in Water ￥880 In-stock
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100 mg ￥2300 In-stock
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生物活性

Cisatracurium besylate (51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

IC50 & Target

AChR alpha-2[1][2].
体外研究
(In Vitro)

Cisatracurium Besylate (51W89) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a bisbenzyltetrahydroisoquinolinium agent with an intermediate duration of action. Cisatracurium Besylate (51W89) is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture [1, 2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1243.48

Formula

C65H82N2O18S2
CAS 号

96946-42-8
中文名称

顺苯磺酸阿曲库铵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

H2O : ≥ 50 mg/mL (40.21 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8042 mL 4.0210 mL 8.0419 mL
5 mM 0.1608 mL 0.8042 mL 1.6084 mL
10 mM 0.0804 mL 0.4021 mL 0.8042 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Dear, G.J., et al., Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom, 1995. 9(14): p. 1457-64.

    [2]. Serra, C.S. and A.C. Oliveira, Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle. Fundam Clin Pharmacol, 2006. 20(3): p. 291-8.

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