AGN 194078

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AGN 194078 

AGN 194078 是一个有选择性的 RARα 激动剂，其 Kd 和 EC50 值分别为 3 和 112 nM。

AGN 194078

AGN 194078 Chemical Structure

CAS No. : 321995-62-4

规格 价格 是否有货 数量
1 mg ￥11000 In-stock
5 mg ￥16500 In-stock
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AGN 194078 相关产品

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生物活性

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

IC50 & Target

RARα

112 nM (EC50)

RARα

3 nM (Kd)

体外研究
(In Vitro)

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

403.42

Formula

C22H23F2NO4
CAS 号

321995-62-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.

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