Bax activator-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bax activator-1 

Bax activator-1 (compound 106) 是一种 Bax 激活剂,诱导 Bax 依赖性肿瘤细胞凋亡。

Bax activator-1

Bax activator-1 Chemical Structure

CAS No. : 1638526-94-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].

IC50 & Target

Bax

 

体外研究
(In Vitro)

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration: 20 μM, 40 μM , 60 μM , 80 μM
Incubation Time: 48 hours
Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.

体内研究
(In Vivo)

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1]
Dosage: 40 mg/kg
Administration: Given i.p., each day for 13 days
Result: Exhibited anti-tumor activity as a single-agent.

分子量

488.62

Formula

C29H36N4O3

CAS 号

1638526-94-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务