NAMPT inhibitor-linker 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NAMPT inhibitor-linker 1 

NAMPT inhibitor-linker 1 为 ADC 的一部分，由一种 NAMPT 的抑制剂作为有效载荷和一个连接物组成。ADC-3 由一个 NAMPT inhibitor-linker 1 和一个 anti-c-Kit 单克隆抗体组成，对表达 c-Kit 的细胞具有抑制作用，比如 GIST-T1 和 NCI-H526 细胞，IC50 值分别为 <3 pM 和 9 pM。

NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 1 Chemical Structure

CAS No. : 2241019-57-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pm and 9 pm, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female scid-beige (SCID bg) mice[1]
Dosage: 20 mg/kg
Administration: A single intravenous injection (i.v.) for 28 days
Result: Significantly inhibited the growth of tumor in mice.

分子量

668.71

Formula

C36H37FN6O6
CAS 号

2241019-57-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务