AcLysValCit-PABC-DMAE-SW-163D

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AcLysValCit-PABC-DMAE-SW-163D 

AcLysValCit-PABC-DMAE-SW-163D 是抗体偶联药物的一部分 (drug-linker conjugates for ADC), 由天然的双嵌入剂SW-163D 和 linker AcLysValCitPABC-DMAE 偶联构成。

AcLysValCit-PABC-DMAE-SW-163D

AcLysValCit-PABC-DMAE-SW-163D Chemical Structure

CAS No. : 2411007-69-5

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生物活性

AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1817.05

Formula

C85H113N19O22S2
CAS 号

2411007-69-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ratnayake AS, et al. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjug Chem. 2018 Dec 13. doi: 10.1021/acs.bioconjchem.8b00843.

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