ODM-204

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ODM-204 

ODM-204是新型非甾体类的雄激素受体CYP17A1酶双抑制剂,IC50分别为80 nM和22 nM。

ODM-204

ODM-204 Chemical Structure

CAS No. : 1642818-64-1

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生物活性

ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.

IC50 & Target

IC50: 80 nM (Androgen receptor), 22 nM (CYP17A1 enzyme)[1]

Clinical Trial

分子量

374.40

Formula

C20H21F3N4

CAS 号

1642818-64-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760(18)30078-5.

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