AEM1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

AEM1 

AEM1 是一种 Nrf2 抑制剂。AEM1 降低 A549 细胞中 Nrf2 依赖基因的表达,并在体外和体内抑制 A549 细胞的生长。

AEM1

AEM1 Chemical Structure

CAS No. : 1030123-90-0

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生物活性

AEM1 is a Nrf2 inhibitor[1]. AEM1 reduces the expressions of Nrf2-dependent genes in A549 cells and inhibits the growth of A549 cells in vitro and in vivo[2].

分子量

379.41

Formula

C20H14FN3O2S

CAS 号

1030123-90-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. DeNicola GM, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9.

    [2]. Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10(10):2193-8.

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