CAY10594

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CAY10594 

CAY10594 是一种有效的磷脂酶 D2 (PLD2) 抑制剂(体外 IC50=140 nM，细胞 IC50=110 nM)。CAY10594 在体外高度抑制乳腺癌细胞的侵袭性迁移，并通过调节磷酸化 GSK-3β/JNK 轴改善扑热息痛诱导的急性肝损伤。

CAY10594

CAY10594 Chemical Structure

CAS No. : 1130067-34-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CAY10594 is a potent phospholipase D2 (PLD2) inhibitor both in vitro (IC50=140 nM) and in cells (IC50=110 nM)[1]. CAY10594 strongly inhibits the invasive migration of breast cancer cells in vitro and ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis[2].

分子量

428.53

Formula

C26H28N4O2
CAS 号

1130067-34-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

    [2]. Lee SK, et al. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019 May 10;9(1):7242.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务