9-Hydroxyellipticine hydrochloride

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9-Hydroxyellipticine hydrochloride 

9-Hydroxyellipticine hydrochloride 是 Topo II 和RyR 的抑制剂。9-Hydroxyellipticine hydrochloride 具有抗肿瘤、抗氧化和释放儿茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 对 Hela S-3 和293T 细胞的IC50 值分别为1.6 μM 和1.2μM。

9-Hydroxyellipticine hydrochloride

9-Hydroxyellipticine hydrochloride Chemical Structure

CAS No. : 52238-35-4

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生物活性

9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

IC50 & Target

Topoisomerase II

 

体外研究
(In Vitro)

9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three- to five-month-old C57B1/6 male mice[1].
Dosage: 5 or 10 mg/kg.
Administration: IP.
Result: Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.

分子量

298.77

Formula

C17H15ClN2O
CAS 号

52238-35-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6.

    [2]. Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8.

    [3]. Naoya Sato, et al. Synthesis and in vitro Antitumor Activity of 9-Hydroxyellipticine Derivatives with Glucose Conjugation via Triazolylmethyl Succinate Linker. Heterocycle, Vol. 92, NO 4, 2016.

    [4]. Ohashi M, et al. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27.

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