NSC624206

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NSC624206 

NSC624206 是一种泛素 E1 (UBA1) 抑制剂，其 IC50 值为 ~9 μM。NSC624206 特异性地阻断泛素-硫代酯的形成，但对泛素腺化无影响。

NSC624206

NSC624206 Chemical Structure

CAS No. : 13116-77-3

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生物活性

NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].

IC50 & Target

IC50: ~9 μM (ubiquitin E1)[1]
体外研究
(In Vitro)

NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1].
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1].
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Kip16 cells
Concentration: 10 nM-10 μM
Incubation Time: 24 hours
Result: Induced accumulation of p27.

分子量

410.51

Formula

C19H33Cl2NS2
CAS 号

13116-77-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr;17(4):421-34.

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