Pifithrin-β(Synonyms: PFT β; Cyclic Pifithrin-α)

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Pifithrin-β (Synonyms: PFT β; Cyclic Pifithrin-α)

Pifithrin-β (PFT β) 是有效地 p53 抑制剂，IC50 值为 23 μM。

Pifithrin-β(Synonyms: PFT β; Cyclic Pifithrin-α)

Pifithrin-β Chemical Structure

CAS No. : 60477-34-1

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Pifithrin-β 的其他形式现货产品:

Pifithrin-β hydrobromide

生物活性

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

IC50 & Target

IC50: 23 μM (p53)[1]
体外研究
(In Vitro)

Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.38

Formula

C16H16N2S
CAS 号

60477-34-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.

    [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.

    [3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.

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