Antitumor agent-45

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Antitumor agent-45 

Antitumor agent-45 (Compound 21) 可诱导 A549 细胞凋亡并将细胞阻滞在 G0/G1 和 G2/M期。Antitumor agent-45 (Compound 21) 抑制c-Met 表达。

Antitumor agent-45

Antitumor agent-45 Chemical Structure

CAS No. : 2581082-74-6

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生物活性

Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells[1].

体外研究
(In Vitro)

Antitumor agent-45 (Compound 21) enhibits IC50 values of 1.06, 10.87 and 0.11 μM in A549, Hela and MCF-7 cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

570.37

Formula

C28H17BrFN5O3
CAS 号

2581082-74-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jianqing Zhang, et al. Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo. Eur J Med Chem. 2022 Apr 5;233:114215.

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