Antitumor agent-28

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antitumor agent-28 

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

Antitumor agent-28

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

512.62

Formula

C25H32N6O4S

CAS 号

2097499-67-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 9

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 9  纯度: 95.93%

Anticancer agent 9,一种甘氨酸衍生物,是一种抗癌剂。Anticancer agent 9 可以抑制骨髓性白血病和人前列腺癌的肿瘤细胞活力。

Anticancer agent 9

Anticancer agent 9 Chemical Structure

CAS No. : 592542-61-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer[1].

体外研究
(In Vitro)

Anticancer agent 9 (compound 24) (96 h) inhibits the cell growth, with IC50s of 0.1 μM and 0.1 μM for K562 and DU145 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

465.52

Formula

C22H27NO8S

CAS 号

592542-61-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Pallela VR, et, al. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910•Na (Rigosertib®), a phase III clinical stage anti-cancer agent. Org Biomol Chem. 2013 Mar 28;11(12):1964-77.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antitumor agent-28

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antitumor agent-28 

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

Antitumor agent-28

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

512.62

Formula

C25H32N6O4S

CAS 号

2097499-67-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antitumor agent-28

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antitumor agent-28 

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

Antitumor agent-28

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

512.62

Formula

C25H32N6O4S

CAS 号

2097499-67-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 9

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 9  纯度: 95.93%

Anticancer agent 9,一种甘氨酸衍生物,是一种抗癌剂。Anticancer agent 9 可以抑制骨髓性白血病和人前列腺癌的肿瘤细胞活力。

Anticancer agent 9

Anticancer agent 9 Chemical Structure

CAS No. : 592542-61-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer[1].

体外研究
(In Vitro)

Anticancer agent 9 (compound 24) (96 h) inhibits the cell growth, with IC50s of 0.1 μM and 0.1 μM for K562 and DU145 cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

465.52

Formula

C22H27NO8S

CAS 号

592542-61-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Pallela VR, et, al. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910•Na (Rigosertib®), a phase III clinical stage anti-cancer agent. Org Biomol Chem. 2013 Mar 28;11(12):1964-77.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 9

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 9  纯度: 95.93%

Anticancer agent 9,一种甘氨酸衍生物,是一种抗癌剂。Anticancer agent 9 可以抑制骨髓性白血病和人前列腺癌的肿瘤细胞活力。

Anticancer agent 9

Anticancer agent 9 Chemical Structure

CAS No. : 592542-61-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer[1].

体外研究
(In Vitro)

Anticancer agent 9 (compound 24) (96 h) inhibits the cell growth, with IC50s of 0.1 μM and 0.1 μM for K562 and DU145 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

465.52

Formula

C22H27NO8S

CAS 号

592542-61-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Pallela VR, et, al. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910•Na (Rigosertib®), a phase III clinical stage anti-cancer agent. Org Biomol Chem. 2013 Mar 28;11(12):1964-77.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antitumor agent-62

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antitumor agent-62 

Antitumor agent-62 (Compound 47) 是一种释放 NO 的抗肿瘤剂。Antitumor agent-62 对癌细胞具有抗增殖效果。Antitumor agent-62 激活线粒体凋亡 (apoptosis) 通路,阻滞细胞周期于 G2/M 期。

Antitumor agent-62

Antitumor agent-62 Chemical Structure

CAS No. : 2460735-29-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase[1].

体外研究
(In Vitro)

Antitumor agent-62 (Compound 47) shows antiproliferative activity with IC50 values of 1.23 ± 0.10, 1.91 ± 0.14, 2.81 ± 0.13, 4.18 ± 0.15 and 9.16 ± 0.38 μM against MDA-MB-231, MCF-7, HepG2, A549 and LO2 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

489.46

Formula

C21H19N3O9S

CAS 号

2460735-29-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shi Z, et al. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 Aug 15;200:112386.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antitumor agent-63

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antitumor agent-63 

Antitumor agent-63 (Compound 40),20 (S)-O-linked camptothecin (CPT) 糖复合物,是一种抗肿瘤剂,对正常细胞无毒性。Antitumor agent-63 具有高稳定性和很弱的 topoisomerase I (Topo I) 直接抑制效果。

Antitumor agent-63

Antitumor agent-63 Chemical Structure

CAS No. : 1627600-90-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].

IC50 & Target

Top1

 

体外研究
(In Vitro)

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC50 values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

846.79

Formula

C38H46N4O18

CAS 号

1627600-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

Cell Assay

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 47

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 47 

Anticancer agent 47 (compound 4j) 是一种有效的抗癌剂。Anticancer agent 47 显示出抗增殖活性。Anticancer agent 47 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 47 在体内显示出抗肿瘤活性。

Anticancer agent 47

Anticancer agent 47 Chemical Structure

CAS No. : 2461795-23-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo[1].

体外研究
(In Vitro)

Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1].
Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1].
Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HepG2, H596 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively.

体内研究
(In Vivo)

Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (HepG2 xenografts)[1]
Dosage: 20 mg/kg
Administration: I.v.; once every 2 days for 19 days
Result: Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.

分子量

366.39

Formula

C19H14N2O4S

CAS 号

2461795-23-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wu L, et al. Synthesis and biological evaluation of β-lapachone-monastrol hybrids as potential anticancer agents. Eur J Med Chem. 2020 Oct 1;203:112594.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 56

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 56 

Anticancer agent 56 (compound 4d) 是一种具有类似药物特性的强效抗癌剂,对多种肿瘤细胞系具有抗癌活性 (IC50<3 μm)。anticancer agent 56 诱导细胞周期阻滞在 g2>ROS,上调 BAX,下调 Bcl-2,激活 caspases 3, 7, 9 起到抗癌作用。

Anticancer agent 56

Anticancer agent 56 Chemical Structure

CAS No. : 2241915-59-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μm). anticancer agent 56 induces cell cycle arrest at g2>apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9[1].

IC50 & Target

IC50: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3[1]

分子量

383.83

Formula

C20H18ClN3O3

CAS 号

2241915-59-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ashour HF, et al. 1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226. Eur J Med Chem. 2020;189:112062.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 44

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 44 

Anticancer agent 44 (compound 2a) 是一种有效的选择性抗癌剂。Anticancer agent 44 在癌细胞中显示出细胞毒活性。Anticancer agent 44 诱导细胞凋亡 (apoptosis)。Anticancer agent 44 对人血的活化淋巴细胞具有低毒性。

Anticancer agent 44

Anticancer agent 44 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 44 (compound 2a) is a potent anticancer agent. Anticancer agent 44 shows cytotoxicity activity in cancer cells. Anticancer agent 44 induces apoptosis. Anticancer agent 44 shows low toxicity towards activated lymphocytes of human blood[1].

体外研究
(In Vitro)

Anticancer agent 44 (compound 2a) (0-100 µM; 72 h) shows antitumor activity with GI50s of 3.40, 63.90, 7.95, 6.45, 70.30, 6.65, 9.18, 6.00, 8.93, 65.90, >100 µM for Jurkat, A549, MCF-7, MDA-MB-231, KB3-1, HeLa, HCT-116, HCT-116 p53-/-, U251, SK-OV-3, HaCaT cells, respectively[1].
Anticancer agent 44 (1.5 µM; 24 h) induces apoptosis by increases the expression of caspase 3, Bax and decreases the amount of anti-apoptotic Bcl-2 protein[1].
Anticancer agent 44 (0-2 µM; 24, 48 h) shows low toxicity towards normal human keratinocytes of HaCaT line and mitogen-activated lymphocytes of peripheral blood of healthy human donor[1].
Anticancer agent 44 dose not induce significant DNA damage and changes in morphology of mitogen-activated lymphocytes of peripheral blood of healthy donor[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

534.39

Formula

C22H13Cl2N3O5S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Finiuk N, et al. Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation. Eur J Med Chem. 2022 May 2;238:114422.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 53

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 53 

Anticancer agent 53 是一种强效抗癌剂。 Anticancer agent 53 显示出体外细胞毒性。Anticancer agent 53 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S/G2/M 期。Anticancer agent 53 具有抗肿瘤活性且无明显毒性。

Anticancer agent 53

Anticancer agent 53 Chemical Structure

CAS No. : 1926985-18-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity[1].

体外研究
(In Vitro)

Anticancer agent 53 (compound c20) (0-1000 nM; 72 h) shows cytotoxicity with IC50s of 2.3, 42.0, 4.3, 96.3, 24.0, 47.4 nM for Hep3B, MCF7, A549, MDA-MB-231, KB, KB-vin cells, respectively[1].
Anticancer agent 53 (0.025, 0.05, 0.1 µM; 48 h) induces apoptosis and cell cycle arrest in S/G2/M phases[1].
Anticancer agent 53 (0.1. 0.2 µM; 6 h) inhibits topoisomerase I activity in A549 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced cell cycle arrest in S/G2/M phases.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced apoptosis with the proapoptotic protein Caspase-3 and Bax were up-regulated and anti-apoptotic Bcl-2 was down-regulated.

体内研究
(In Vivo)

Anticancer agent 53 (5, 25 and 50 mg/kg; IP) shows no apparent toxicity to mouse liver, kidney and hemopoietic system[1].
Anticancer agent 53 (2 mg/kg; i.v; every other day for two weeks) shows antitumor effect in HCC mouse model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice[1]
Dosage: 5, 25 and 50 mg/kg (saline with 5% DMSO and 5% Cremophor EL)
Administration: I.p.
Result: Showed no body weight loss, no significant liver damage, no significant damage occurred in spleens and livers.
Animal Model: 6-8 weeks Female BALB/c nude mice (Hep3B cells)[1]
Dosage: 1, 2 mg/kg
Administration: I.v., every other day for total 7 doses
Result: Significantly inhibited tumor growth with an average body weight of 24 g and an average tumor volume of 3800 mm[3] at 1 mg/kg and an average body weight of 22 g and average tumor volume 2380 mm[3] at 2 mg/kg.
Animal Model: 6-8 weeks FVB/N mice (HCC mouse model)[1]
Dosage: 2 mg/kg
Administration: I.v.; every other day for two weeks
Result: Inhibited the tumor growth and reduced the liver weights, and t inhibited proliferation of HCC tissues.

分子量

600.62

Formula

C31H25FN4O6S

CAS 号

1926985-18-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang CJ, et al. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. Eur J Med Chem. 2020 Feb 1;187:111971.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antibacterial agent 33

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antibacterial agent 33 

Antibacterial agent 3,一种抗菌剂,可降低抗菌剂 Ceftazidime 的MIC数值。

Antibacterial agent 33

Antibacterial agent 33 Chemical Structure

CAS No. : 1426572-59-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antibacterial agent 33, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime[1].

分子量

359.36

Formula

C12H17N5O6S

CAS 号

1426572-59-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sachin Bhagwat, et al. 1,6- diazabicyclo [3,2,1] octan- 7 – one derivatives and their use in the treatment of bacterial infections.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antibacterial agent 33

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antibacterial agent 33 

Antibacterial agent 3,一种抗菌剂,可降低抗菌剂 Ceftazidime 的MIC数值。

Antibacterial agent 33

Antibacterial agent 33 Chemical Structure

CAS No. : 1426572-59-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antibacterial agent 33, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime[1].

分子量

359.36

Formula

C12H17N5O6S

CAS 号

1426572-59-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sachin Bhagwat, et al. 1,6- diazabicyclo [3,2,1] octan- 7 – one derivatives and their use in the treatment of bacterial infections.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antiproliferative agent-8

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antiproliferative agent-8 

Antiproliferative against-9 (Compound 5a) 是一种抗癌剂。Antiproliferative against-9 具有抗增殖活性。Antiproliferative against-9 显着增加 P53 水平。

Antiproliferative agent-8

Antiproliferative agent-8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antiproliferative against-9 (Compound 5a) is an anti-cancer agent. Antiproliferative against-9 has antiproliferative activity. Antiproliferative against-9 significantly increases the P53 levels[1].

分子量

405.83

Formula

C22H16ClN3O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ramadan M, et al. Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity. Bioorg Chem. 2020;105:104392.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antibacterial agent 33

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Antibacterial agent 33 

Antibacterial agent 3,一种抗菌剂,可降低抗菌剂 Ceftazidime 的MIC数值。

Antibacterial agent 33

Antibacterial agent 33 Chemical Structure

CAS No. : 1426572-59-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Antibacterial agent 33, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime[1].

分子量

359.36

Formula

C12H17N5O6S

CAS 号

1426572-59-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sachin Bhagwat, et al. 1,6- diazabicyclo [3,2,1] octan- 7 – one derivatives and their use in the treatment of bacterial infections.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 40

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 40 

Anticancer agent 40 (compound 3e) 是一种有效的抗癌剂。Anticancer agent 40 显示出抗癌活性对 SKBR-3、SKOV-3、PC-3、U-87、HDF 细胞的 IC50s 分别为 0.94、0.98、0.96、0.95、2.13 nM。

Anticancer agent 40

Anticancer agent 40 Chemical Structure

CAS No. : 2760658-33-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC50s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively[1].

分子量

439.50

Formula

C25H29NO6

CAS 号

2760658-33-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyta K,et al. Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs. J Enzyme Inhib Med Chem. 2022 Dec;37(1):597-605.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 49

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 49 

Anticancer agent 49 (compound 69) 是一种广谱抗癌剂。Anticancer agent 49 抑制微管蛋白聚合。Anticancer agent 49 表现出抗增殖活性。Anticancer agent 49 具有研究实体瘤和血液肿瘤的潜力。

Anticancer agent 49

Anticancer agent 49 Chemical Structure

CAS No. : 2395009-34-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 49 (compound 69) is a broad spectrum anticancer agent. Anticancer agent 49 inhibits tubulin polymerization. Anticancer agent 49 shows antiproliferative activity. Anticancer agent 49 has the potential for the research of solid and hematological tumors[1].

体外研究
(In Vitro)

Anticancer agent 49 (compound 69) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.38 µM and 15 nM, respectively[1].
Anticancer agent 49 shows antiproliferative activity with IC50s of 5, 8, 10, 10, 12 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1].
Anticancer agent 49 shows growth inhibition with IC50s of 22, 48, 24, 303, 147, 41, 34, 153, 61, 58 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

443.49

Formula

C26H25N3O4

CAS 号

2395009-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Puxeddu M, et al. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 51

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 51 

Anticancer agent 51 (compound 3d) 是一种有效的抗癌剂,Ki 为 731.62 nM。Anticancer agent 51 显示出抗癌活性。Anticancer agent 51 具有研究前列腺癌的潜力。

Anticancer agent 51

Anticancer agent 51 Chemical Structure

CAS No. : 2521777-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 51 (compound 3d) is a potent anticancer agent with an Ki of 731.62 nM. Anticancer agent 51 shows anticancer activity. Anticancer agent 51 has the potential for the research of prostate cancer[1].

体外研究
(In Vitro)

Anticancer agent 51 (compound 3d) shows anticancer activity with IC50s of 64.3, 62.2, 92.8 µM for PC-3, DU-145, LNCaP cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

447.47

Formula

C22H20F3N3O2S

CAS 号

2521777-38-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Birgül K, et al. Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives. Eur J Med Chem. 2020 Dec 15;208:112841.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Anticancer agent 50

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Anticancer agent 50 

Anticancer agent 50 (compound 6) 是一种有效的 ABCB1 外排泵调节剂。Anticancer agent 50 显示细胞毒作用和抗增殖作用。Anticancer agent 50 降低细胞周期蛋白 D1 的表达并诱导 p53 表达。Anticancer agent 50 具有研究T淋巴瘤的潜力。

Anticancer agent 50

Anticancer agent 50 Chemical Structure

CAS No. : 2487457-15-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma[1].

体外研究
(In Vitro)

Anticancer agent 50 (compound 6) (0-100 µM) shows cytotoxic effects with IC50s of 0.67, 0.90 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0-100 µM) shows antiproliferative effects with IC50s of 3.84, 1.34 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0.1, 0.5, 2 µM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression[1].
Anticancer agent 50 (0.1, 0.5, 2, 10 µM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: JURKAT cells
Concentration: 0.1, 0.5, 2 µM
Incubation Time: 24 h
Result: Significantly reduced cyclin D1 expression and increased the level of p53.

分子量

563.55

Formula

C30H32N2O4Se

CAS 号

2487457-15-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ali W, et al. Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma. Eur J Med Chem. 2020 Aug 15;200:112435.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务