CDK9-IN-14

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK9-IN-14 

CDK9-IN-14 是一种有效且具有选择性的 CDK9 抑制剂，IC50 为 6.92 nM。CDK9-IN-14 对 MV4;11 细胞和体内肿瘤模型有较强的抑制作用，选择性好，毒性低，副作用少。

CDK9-IN-14

CDK9-IN-14 Chemical Structure

CAS No. : 2650640-17-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].

IC50 & Target[1]

CDK9

6.92 nM (IC50)

体外研究
(In Vitro)

CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1]
Dosage: 5 mg/kg
Administration: p.o., qd, for 9 days
Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.

分子量

419.42

Formula

C21H23F2N3O4
CAS 号

2650640-17-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. WANG Zhenyu. Compound as cyclin-dependent kinase 9 inhibitor and use thereof. WO2021115335A1

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务