Antitumor agent-38

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Antitumor agent-38 

Antitumor agent-38 是一种有效的抗肿瘤剂。Antitumor agent-38 在肿瘤细胞中显示抗增殖活性。 Antitumor agent-38 诱导细胞周期停滞在 S 和 G2M 晚期而不干扰微管的形成和细胞形态的变化。

Antitumor agent-38

Antitumor agent-38 Chemical Structure

CAS No. : 2744193-34-6

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生物活性

Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

体外研究
(In Vitro)

Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 µM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].
Antitumor agent-38 (0.58, 1.74 µM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.85, 1.74 µM
Incubation Time: 24 h
Result: Cells were arrested at the late S and G2/M phase.

分子量

380.44

Formula

C22H24N2O4

CAS 号

2744193-34-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xie L,et al. Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents. ACS Med Chem Lett. 2021; 12(12):1948-1954.

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