Antitumor agent-38

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-38 

Antitumor agent-38 是一种有效的抗肿瘤剂。Antitumor agent-38 在肿瘤细胞中显示抗增殖活性。 Antitumor agent-38 诱导细胞周期停滞在 S 和 G2M 晚期而不干扰微管的形成和细胞形态的变化。

Antitumor agent-38

Antitumor agent-38 Chemical Structure

CAS No. : 2744193-34-6

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生物活性

Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

体外研究
(In Vitro)

Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 µM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].
Antitumor agent-38 (0.58, 1.74 µM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.85, 1.74 µM
Incubation Time: 24 h
Result: Cells were arrested at the late S and G2/M phase.

分子量

380.44

Formula

C22H24N2O4
CAS 号

2744193-34-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xie L,et al. Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents. ACS Med Chem Lett. 2021; 12(12):1948-1954.

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