Apaziquone(Synonyms: EO-9; NSC 382 459)

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Apaziquone (Synonyms: EO-9; NSC 382 459)

Apaziquone (EO-9) 是丝裂霉素 C (Mitomycin C) 的类似物,是一种前药,可被氧化还原酶(尤其是 NQO1) 激活产生 DNA 损伤。Apaziquone 具有杀死需氧和/或缺氧癌细胞的能力。Apaziquone 是一种生物还原性烷化剂,可抑制口腔鳞状细胞癌 (OSCC) 细胞的细胞增殖并诱导细胞凋亡。Apaziquone 显着减少免疫功能低下的 NOD/SCID/Crl 小鼠的口腔肿瘤异种移植物体积。

Apaziquone(Synonyms: EO-9;  NSC 382 459)

Apaziquone Chemical Structure

CAS No. : 114560-48-4

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生物活性

Apaziquone (EO-9), an analog of Mitomycin C, is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1). Apaziquone has the ability to kill aerobic and/or hypoxic cancer cells. Apaziquone, a bioreductive alkylating agent, inhibits cell proliferation and induces apoptosis in oral squamous cell carcinoma (OSCC) cells. Apaziquone significantly reduces oral tumor xenograft volume in immunocompromised NOD/SCID/Crl mice[1][2].

分子量

288.30

Formula

C15H16N2O4

CAS 号

114560-48-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gunjan Srivastava, et al. Anticancer Activity of Apaziquone in Oral Cancer Cells and Xenograft Model: Implications for Oral Cancer Therapy. PLoS One. 2015 Jul 24;10(7):e0133735.

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