Globosuxanthone A

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Globosuxanthone A 

Globosuxanthone A 是一种二氢黄嘌呤酮，对禾谷镰刀菌、茄镰刀菌和灰霉病菌具有明显的抗真菌活性，MIC 值分别为 4、8 和 16 μg/mL。具有抗癌活性。

Globosuxanthone A

Globosuxanthone A Chemical Structure

CAS No. : 917091-74-8

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生物活性

Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].

体外研究
(In Vitro)

Globosuxanthone A shows cytotoxicities against NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, DU-145 cells (IC50=0.65-3.6 µM)[1].
Globosuxanthone A impairs cell cycle progression of NCI-H460 and PC-3M cells leading to accumulation in the G2/M and S phases [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

304.25

Formula

C15H12O7
CAS 号

917091-74-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572.

    [2]. Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923.

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