EGFR-IN-29

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EGFR-IN-29 

EGFR-IN-29 是一种有效的 EGFR 抑制剂,案例 J-022,专利为 WO2021160087。

EGFR-IN-29

EGFR-IN-29 Chemical Structure

CAS No. : 2682200-93-5

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生物活性

EGFR-IN-29 is a potent EGFR inhibitor, example J-022, extracted from Patent WO2021160087[1].

IC50 & Target[1]

EGFRT790M

 

体外研究
(In Vitro)

EGFR-IN-29 inhibits Ba/F3 cells with stable overexpression of △19del/T790M/C797S mutant genes, cells overexpressing EGFR WT and A431 carrying EGFR WT with IC50 values of 6.8 nM, 151 nM and 1128 nM, respectively.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

733.68

Formula

C36H46BrN8O2P

CAS 号

2682200-93-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xiangyong Liu. Quinolyl phosphine oxide compound, and composition and application thereof. Patent WO2021160087.

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