Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

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Roslin 2 bromide (Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种具有抗癌作用的 p53 再激活剂。Roslin 2 bromide 结合 FAK,破坏 FAK 和 p53 的结合。

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide Chemical Structure

CAS No. : 29574-21-8

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生物活性

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

体外研究
(In Vitro)

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

311.22

Formula

C13H19BrN4

CAS 号

29574-21-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

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