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TLR7/8 antagonist 1

TLR7/8 Antagonist 1 (Compound 16c) 是 TLR7/8 的有效拮抗剂，IC₅₀ 值分别为 3.91 和 2.19 μM。TLR7/8 Antagonist 1 是一种咪唑喹啉衍生物化合物。Toll 样受体 (TLR) 7 和 8 是开发用于治疗传染病、癌症和自身免疫性疾病的免疫调节药物的关键靶点。

TLR7/8 antagonist 1 Chemical Structure

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生物活性	TLR7/8 Antagonist 1 (Compound 16c) is the potent antagonist of TLR7/8 with IC₅₀s of 3.91 and 2.19 μM, respectively. TLR7/8 Antagonist 1 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders^[1].
分子量	417.50
Formula	C₂₄H₂₇N₅O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.

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