HSP70-IN-3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HSP70-IN-3 

HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50 分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性，并降低致癌转录因子 GLI1 的表达。

HSP70-IN-3

HSP70-IN-3 Chemical Structure

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生物活性

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].

IC50 & Target

IC50: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2[1]
体外研究
(In Vitro)

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 5 μM
Incubation Time: 72 hours
Result: Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.

分子量

883.23

Formula

C48H78N6O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wen J, et al. Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma. Eur J Med Chem. 2022;228:114005.

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