TMI-1(Synonyms: WAY-171318)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TMI-1 (Synonyms: WAY-171318)

TMI-1 是去整合素金属酶 17 (ADAM17) 和其它基质金属蛋白酶 MMPs 的有效抑制剂。TMI-1 能有效抑制 LPS 诱导的人原代单核细胞和人全血中 TNF-α 的分泌。TMI-1 在三阴性 (TN) 和 ERBB2 过度表达的乳腺肿瘤细胞系中选择性诱导 Caspase 依赖的细胞凋亡。

TMI-1(Synonyms: WAY-171318)

TMI-1 Chemical Structure

CAS No. : 287403-39-8

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生物活性

TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood[1]. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines[2].

IC50 & Target

ADAM17

8.4 nM (IC50)

分子量

398.50

Formula

C17H22N2O5S2
CAS 号

287403-39-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et al. Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. J Pharmacol Exp Ther. 2004 Apr;309(1):348-55.

    [2]. Mezil L, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One. 2012;7(9):e43409.

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