Antitumor agent-49

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Antitumor agent-49 

Antitumor agent-49 (Compound 10) 是一种含有 NO 供体的 Harmine 衍生物-呋喃杂化物,具有抗肿瘤活性。Antitumor agent-49 对 HepG2 细胞具有细胞毒活性,IC50 为 1.79 µM,并能在体外产生高水平的 NO。

Antitumor agent-49

Antitumor agent-49 Chemical Structure

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生物活性

Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro[1].

分子量

841.77

Formula

C42H41BrN4O8S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhezhe Li, et al. Synthesis of harmine-nitric oxide donor derivatives as potential antitumor agents. Bioorg Med Chem Lett. 2022 Mar 24;65:128698.

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