Ph-Ph+

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ph-Ph+ 

Ph-Ph+ 是一种半质子型化合物,由菲咯啉 (ph) 二聚化产生。Ph-Ph+ 具有抗肿瘤、抗菌和抗真菌活性。

Ph-Ph+

Ph-Ph+ Chemical Structure

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生物活性

Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities[1].

体外研究
(In Vitro)

Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) inhibits the various tumor cell proliferation in a concentration- and time-dependent manner for H22, U251MG, human neuroblastoma SH-SY5Y cell line, mouse melanoma B16 cell line, and human lung adenocarcinoma A549 cell line). , Ph-Ph+ does not affect the viabilities of human L02 cells and HUVEC cells. Under an optical microscope, Ph-Ph+-treated tumor cells shrank and exhibited apoptotic bodies. Ph-Ph+ has a selective antitumor effect through inducing cell apoptosis[1].
Ph-Ph+ has broad-spectrum antibacterial and antifungal activities, and drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The tumor-bearing mice were prepared using the subcutaneous transplantation mouse hepatoma H22 cell line. Ph-Ph+ (2-8 mg/kg; i.v; for 8 days) treatment reduces tumor volume and weight in a dose-dependent manner[1].
In animal models of liver cancer with fungal infection, the Ph-Ph+ (2-8 mg/kg; i.v; once a day for 9 days) retards proliferation of hepatoma cells in tumor-bearing mice and remedies pneumonia and encephalitis caused by Cryptococcus neoformans[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

361.42

Formula

C24H17N4+

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zizhen Zhao, et al.Synthesis of Hemiprotonic Phenanthroline-Phenanthroline + Compounds with both Antitumor and Antimicrobial Activity. J Med Chem. 2022 Feb 10;65(3):2532-2547.

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