HDAC-IN-27

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HDAC-IN-27 

HDAC-IN-27 是一种有效的口服活性 HDAC I 类选择性抑制剂,对 HDAC1-3 的 IC50 值范围为 0.43 至 3.01 nM。抗急性髓系白血病 (AML) 活性。

HDAC-IN-27

HDAC-IN-27 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

HDAC-IN-27 是一种有效的口服活性 HDAC I 类选择性抑制剂,对 HDAC1-3 的 IC50 值范围为 0.43 至 3.01 nM。抗急性髓系白血病 (AML) 活性。

体外研究
(In Vitro)

In wt-p53 MV4-11 cells, HDAC-IN-27 (11h) leads to pro-caspase-3 cleavage, apparent apoptotic cell death, and accumulation of sub-G1 cell population while inducing G2/M arrest in HL60 cells with no evidence of apoptosis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

350.41

Formula

C20H22N4O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jiang Y, et al. Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo. J Med Chem. 2022;65(1):285-302.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务