MIF2-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

MIF2-IN-1 

MIF2-IN-1 (compound 5d) 是一种有效的 MIF2 互变异构酶抑制剂,IC50 为 1.0 μM。MIF2-IN-1 通过 MAPK 通路诱导细胞周期停滞来抑制非小细胞肺癌细胞的增殖。MIF2-IN-1 具有研究癌症疾病的潜力。

MIF2-IN-1

MIF2-IN-1 Chemical Structure

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生物活性

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].

IC50 & Target

IC50: 1.0 μM (MIF2)[1]

分子量

480.50

Formula

C26H19F3N2O2S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077.

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