Hematin(Synonyms: 羟高铁血红素)

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Hematin (Synonyms: 羟高铁血红素) 纯度: 98.09%

Hematin 是一种含铁卟啉，通过结合止血蛋白 (hemostatic proteins) 诱导其失活的机制抑制凝血因子 (clotting factors) 的活性以及纤维蛋白凝块 (fibrin clot) 的溶解。Hematin 可用于急性卟啉症和癌症的研究。

Hematin(Synonyms: 羟高铁血红素)

Hematin Chemical Structure

CAS No. : 15489-90-4

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生物活性

Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5].

体外研究
(In Vitro)

Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin[2].
Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml[2].
Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)[2].
Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g)[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

633.49

Formula

C34H33FeN4O5
CAS 号

15489-90-4
中文名称

羟高铁血红素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57.

    [2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369.

    [3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43.

    [4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238.

    [5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4.

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