ME-143(Synonyms: NV-143)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ME-143 (Synonyms: NV-143)

ME-143 是第二代肿瘤特异性 NADH 氧化酶 (NADH oxidase) 抑制剂。ME-143 抑制结直肠癌细胞中的 WNT/β-catenin 通路。ME-143 在体外和体内具有广泛的抗癌活性。

ME-143(Synonyms: NV-143)

ME-143 Chemical Structure

CAS No. : 852536-39-1

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生物活性

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].

IC50 & Target

NADH oxidase[1]
体外研究
(In Vitro)

ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: RKO cell; DLD1 cell
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein.

体内研究
(In Vivo)

NADH氧化酶抑制剂

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.37

Formula

C21H18O4
CAS 号

852536-39-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Pintova S, et al. ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells. Anticancer Res. 2017;37(4):1647-1653.

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