DHA-paclitaxel(Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DHA-paclitaxel (Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

DHA-paclitaxel是一种由天然脂肪酸DHA共价连接到紫杉醇的C2′-位置组成的惰性前药。紫杉醇部分与微管蛋白结合，抑制微管的分解，从而抑制细胞分裂。与紫杉醇相比，DHA-paclitaxel更特异性地靶向肿瘤细胞，因为肿瘤细胞吸收大量天然脂肪酸作为生化前体和能量来源。

DHA-paclitaxel(Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

DHA-paclitaxel Chemical Structure

CAS No. : 199796-52-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DHA-paclitaxel is an inert prodrug composed of the natural fatty acid DHA covalently linked to the C2′-position of paclitaxel. The paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Compared to Paclitaxel, DHA-Paclitaxel targets tumor cells more specifically because tumor cells absorb large amounts of natural fatty acids for use as biochemical precursors and energy sources.

分子量

1164.38

Formula

C69H81NO15
CAS 号

199796-52-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sparreboom A, Wolff AC, Verweij J, et al. Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. Clin Cancer Res. 2003;9(1):151-159.

    [2]. Bradley MO, Webb NL, Anthony FH, et al. Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. Clin Cancer Res.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务