Namoline(Synonyms: 萘莫胺)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Namoline (Synonyms: 萘莫胺)

Namoline,一种 γ-pyrone,是选择性、可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,在 HRP 偶联酶测定中的 IC50 为 51 μM。Namoline 损害 LSD1 去甲基化酶活性并阻止细胞增殖。Namoline 具有雄激素依赖性前列腺癌研究的潜力。

Namoline(Synonyms: 萘莫胺)

Namoline Chemical Structure

CAS No. : 342795-11-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].

体外研究
(In Vitro)

Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1].
Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1].
Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

293.58

Formula

C10H3ClF3NO4

CAS 号

342795-11-3

中文名称

萘莫胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dominica Willmann, et al. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer. 2012 Dec 1;131(11):2704-9.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务