cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

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cis-Vaccenic acid (Synonyms: 顺-十八碳烯酸) 纯度: ≥98.0%

cis-Vaccenic acid 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

规格 价格 是否有货 数量
25mg（1.77 M * 0.05 mL in Ethanol） ￥700 In-stock
50mg（1.77 M * 0.1 mL in Ethanol） ￥1100 In-stock
100mg（1.77 M * 0.2 mL in Ethanol） ￥1800 In-stock

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生物活性

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

体外研究
(In Vitro)

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[2]

Cell Line: K562 cells
Concentration: 50 μM, 70 μM and 100 μM
Incubation Time: 48 and 120 hours
Result: Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

分子量

282.46

Formula

C18H34O2
CAS 号

506-17-2
中文名称

顺-十八碳烯酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

    [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

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