3BrB-PP1

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3BrB-PP1 

3BrB-PP1 是一种 ATP 竞争性类似物。3BrB-PP1 可特异性抑制 ATP 结合口袋中发生突变的蛋白激酶的活性。

3BrB-PP1

3BrB-PP1 Chemical Structure

CAS No. : 956025-99-3

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生物活性

3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].

分子量

360.25

Formula

C16H18BrN5

CAS 号

956025-99-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7.

    [2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928.

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