HDAC/BET-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HDAC/BET-IN-1 

HDAC/BET-IN-1 显示对 HDAC1 和 6 的亚微摩尔抑制活性（IC50 = 0.163 μM 和 0.067 μM）和BRD4（Ki = 0.076 μM）抑制活性，并具有有效的抗白血病活性。

HDAC/BET-IN-1

HDAC/BET-IN-1 Chemical Structure

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生物活性

HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity.

分子量

604.71

Formula

C29H40N4O8S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Schäker-Hübner L, et al. 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J Med Chem. 2021 Oct 14;64(19):14620-14646.

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