Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

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Levomefolate-13C5 calcium (Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium 是一种 13C 标记的 Levomefolate (calcium)。Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium Chemical Structure

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生物活性

Levomefolate-13C5 calcium is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

497.44

Formula

C1513C5H18CaN7O6
中文名称

左旋甲状腺素钙 13C5 (钙盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [3]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [4]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [5]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [6]. Levomefolic_acid

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