Oxidopamine-d4 hydrobromide(Synonyms: 6-Hydroxydopamine-d4 hydrobromide; 6-OHDAd4 hydrobromide)

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Oxidopamine-d4 hydrobromide (Synonyms: 6-Hydroxydopamine-d4 hydrobromide; 6-OHDAd4 hydrobromide)

Oxidopamine-d4 (6-Hydroxydopamine-d4) hydrobromide 是 Oxidopamine hydrobromide 的氘代物。Oxidopamine hydrobromide (6-OHDA hydrobromide) 是神经递质多巴胺 (neurotransmitter dopamine) 拮抗剂,是一种广泛使用的神经毒素,可选择性地破坏多巴胺能神经元。

Oxidopamine-d4 hydrobromide(Synonyms: 6-Hydroxydopamine-d4 hydrobromide; 6-OHDAd4 hydrobromide)

Oxidopamine-d4 hydrobromide Chemical Structure

CAS No. : 2733842-05-0

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生物活性

Oxidopamine-d4 (6-Hydroxydopamine-d4) hydrobromide is the deuterium labeled Oxidopamine hydrobromide. Oxidopamine (6-OHDA) hydrobromide, an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

254.11

Formula

C8H8D4BrNO3

CAS 号

2733842-05-0

中文名称

6-羟基多巴胺氢溴酸盐 d4 (氢溴酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.

    [3]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson’s disease. J Neurochem. 2000 Apr;74(4):1605-12.

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