Fluphenazine-d8 dihydrochloride(Synonyms: 盐酸氟奋乃静 d8 (双盐酸盐))

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Fluphenazine-d8 dihydrochloride (Synonyms: 盐酸氟奋乃静 d8 (双盐酸盐))

Fluphenazine-d8 dihydrochloride 是 Fluphenazine dihydrochloride 的氘代物。Fluphenazine二盐酸盐是多巴胺受体D1/D2抑制剂。

Fluphenazine-d8 dihydrochloride(Synonyms: 盐酸氟奋乃静 d8 (双盐酸盐))

Fluphenazine-d8 dihydrochloride Chemical Structure

规格 是否有货
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生物活性

Fluphenazine-d8 dihydrochloride is the deuterium labeled Fluphenazine dihydrochloride. Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

518.49

Formula

C22H20D8Cl2F3N3OS

中文名称

盐酸氟奋乃静 d8 (双盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700.

    [3]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73.

    [4]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43.

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