Vinpocetine-d5(Synonyms: 长春西汀 d5)

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Vinpocetine-d5 (Synonyms: 长春西汀 d5)

Vinpocetine-d5 是 Vinpocetine 的氘代物。Vinpocetine (Ethyl apovincaminate) 是一种长春花生物碱衍生物，可阻断 Na+ 通道。Vinpocetine 抑制 IKK 的 IC50 值为 17.17 μM。Vinpocetine 还是 PDE 抑制剂，并通过直接靶向 IKK 抑制 NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。

Vinpocetine-d5(Synonyms: 长春西汀 d5)

Vinpocetine-d5 Chemical Structure

CAS No. : 2734920-39-7

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生物活性

Vinpocetine-d5 is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

355.48

Formula

C22H21D5N2O2
CAS 号

2734920-39-7
中文名称

长春西汀 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800

    [3]. Patyar S, et al. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep. 2011;63(3):618-28.

    [4]. Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010, Vol. 107, No. 22 9921-9922.

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