Thalidomide-5-propargyne-NH2 hydrochloride

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Thalidomide-5-propargyne-NH2 hydrochloride 

Thalidomide-5-propargyne-NH2 hydrochloride 是一种基于 Thalidomide 的,可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5-propargyne-NH2 hydrochloride 可通过 linker 与靶蛋白配体连接,形成 PROTAC 分子。

Thalidomide-5-propargyne-NH2 hydrochloride

Thalidomide-5-propargyne-NH2 hydrochloride Chemical Structure

CAS No. : 2490402-62-3

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生物活性

Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

347.75

Formula

C16H14ClN3O4

CAS 号

2490402-62-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

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