Cl-4AS-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Cl-4AS-1 

Cl-4AS-1 是一种有效的类固醇雄激素受体 (AR) 激动剂 (IC50 为 12 nM),也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC50 分别为 6 和 10 nM)。

Cl-4AS-1

Cl-4AS-1 Chemical Structure

CAS No. : 188589-66-4

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生物活性

Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

IC50 & Target

IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]

体外研究
(In Vitro)

Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ORX rats[1]
Dosage: 10 mg/kg
Administration: I.s.; 7 days
Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.

分子量

441.01

Formula

C26H33ClN2O2

CAS 号

188589-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376.

    [2]. Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.

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