SW157765

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SW157765 

SW157765 是一种选择性非标准葡萄糖转运蛋白 GLUT8 (SLC2A8) 抑制剂。KRAS/KEAP1 双突变 NSCLC 细胞对 SW157765 选择性敏感,这是由于 KRAS 和 NRF2 双重调节代谢和异生基因调控程序的收敛结果。

SW157765

SW157765 Chemical Structure

CAS No. : 332063-87-3

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生物活性

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

体外研究
(In Vitro)

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

331.32

Formula

C19H13N3O3

CAS 号

332063-87-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269.

    [2]. McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.

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