SiR-COOH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SiR-COOH 

SiR-COOH 可用于跟踪模型药物在 GFP 标记细胞中的位置。

SiR-COOH

SiR-COOH Chemical Structure

CAS No. : 1418275-26-9

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生物活性

SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

体外研究
(In Vitro)

SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

472.61

Formula

C27H28N2O4Si

CAS 号

1418275-26-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7.

    [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

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