Picrasidine Q

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Picrasidine Q 

Picrasidine Q 是从当归植物中提取的生物碱成分,具有抗细胞转化和抗癌作用。Picrasidine Q 诱导人食管癌细胞凋亡和G1 期阻滞,并直接抑制 FGFR2 激酶活性。

Picrasidine Q

Picrasidine Q Chemical Structure

CAS No. : 101219-61-8

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生物活性

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].

IC50 & Target[1]

FGFR2

 

体外研究
(In Vitro)

Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 3 hours
Result: Suppressed downstream signaling of FGFR2 in ESCC cells.

Apoptosis Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 48 and 72 hours
Result: Induced cell cycle arrest and apoptosis.

Cell Cytotoxicity Assay[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 24~72 hours
Result: Suppressed the growth of ESCC cells.

Cell Cycle Analysis[1]

Cell Line: JB6Cl41 cells
Concentration: 0~60 μM
Incubation Time: 30 minutes
Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.

分子量

266.25

Formula

C15H10N2O3

CAS 号

101219-61-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shi Y, et al. FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. J Cell Biochem. 2018;119(2):2231-2239.

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