Lucidin primeveroside(Synonyms: Lucidin 3-O-β-primeveroside)

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Lucidin primeveroside (Synonyms: Lucidin 3-O-β-primeveroside)

Lucidin primeveroside (Lucidin 3-O-β-primeveroside) 是一种存在于茜草根中的蒽醌衍生物,已被用作着色剂和食品添加剂。Lucidin primeveroside 可以代谢转化为基因毒性化合物 Lucidin,随后形成 Lucidin 特异性 DNA 加合物。

Lucidin primeveroside(Synonyms: Lucidin 3-O-β-primeveroside)

Lucidin primeveroside Chemical Structure

CAS No. : 29706-59-0

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生物活性

Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts[1][2].

体内研究
(In Vivo)

Lucidin primeveroside (0.3% in the diet; 4 weeks or 13 weeks) induces Lucidin-specific DNA adduct formation and increases mutation frequencies in mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.49

Formula

C26H28O14

CAS 号

29706-59-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yockey OP, et, al. Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ. Chem Res Toxicol. 2017 Nov 20;30(11):2023-2032.

    [2]. Ishii Y, et, al. Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin-3-O-primeveroside. J Appl Toxicol. 2019 Apr;39(4):650-657.

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