Hippeastrine(Synonyms: 小星蒜碱) | 赛默飞Alfa aesar官网

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Hippeastrine (Synonyms: 小星蒜碱)

Hippeastrine 是一种活性生物碱，对拓扑异构酶 I Top I 具有良好的剂量依赖性抑制作用，IC₅₀ 为7.25 μg/mL。具有抗增殖和抗癌活性。

Hippeastrine Chemical Structure

CAS No. : 477-17-8

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生物活性	Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC₅₀ at 7.25 μg/mL. Antiproliferative and anticancer activities^[1].
体外研究 (In Vitro)	Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC₅₀s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	315.32
Formula	C₁₇H₁₇NO₅
CAS 号	477-17-8
中文名称	小星蒜碱
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6.

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