Hippeastrine(Synonyms: 小星蒜碱)

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Hippeastrine (Synonyms: 小星蒜碱)

Hippeastrine 是一种活性生物碱,对拓扑异构酶 I Top I 具有良好的剂量依赖性抑制作用,IC50 为7.25 μg/mL。具有抗增殖和抗癌活性。

Hippeastrine(Synonyms: 小星蒜碱)

Hippeastrine Chemical Structure

CAS No. : 477-17-8

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生物活性

Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1].

体外研究
(In Vitro)

Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC50s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.32

Formula

C17H17NO5

CAS 号

477-17-8

中文名称

小星蒜碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6.

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