Lurbinectedin-d3(Synonyms: PM01183-d3)

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Lurbinectedin-d3 (Synonyms: PM01183-d3)

Lurbinectedin D3 是 Lurbinectedin 的氘代物。Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂,具有高效的抗肿瘤活性; 抑制 RMG1 和 RMG2 的 IC50 值分别为 1.25 和 1.16 nM。

Lurbinectedin-d3(Synonyms: PM01183-d3)

Lurbinectedin-d3 Chemical Structure

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100 μg ¥6800 In-stock
500 μg ¥15000 In-stock
1 mg ¥24000 In-stock
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生物活性

Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].

分子量

787.89

Formula

C41H41D3N4O10S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

    [2]. Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.

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