Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Spiraeoside (Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside 是具有口服活性的天然产物,具有抗氧化活性,抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside Chemical Structure

CAS No. : 20229-56-5

规格 价格 是否有货
5 mg ¥5700 询问价格 & 货期
10 mg ¥9500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

体外研究
(In Vitro)

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AC16 cells.
Concentration: 1, 5, 10, or 20 μM.
Incubation Time: 0, 24, or 48 hours.
Result: Inhibited AC16 cells viability (20 μM).

体内研究
(In Vivo)

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (6-8 weeks old)[2].
Dosage: 50 mg/kg.
Administration: Oral gavage an hour before inducing the lesions.
Result: Decreased severity of the formed lesions.

分子量

464.38

Formula

C21H20O12

CAS 号

20229-56-5

中文名称

螺旋藻苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.

    [2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

发表评论