WT IDH1 Inhibitor 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

WT IDH1 Inhibitor 2 

WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。

WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

规格 价格 是否有货
5 mg ¥9200 询问价格 & 货期
10 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

体外研究
(In Vitro)

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

501.55

Formula

C28H28FN5O3

CAS 号

1816272-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务