WT IDH1 Inhibitor 2

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WT IDH1 Inhibitor 2 

WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。

WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

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生物活性

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

体外研究
(In Vitro)

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

501.55

Formula

C28H28FN5O3

CAS 号

1816272-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

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