CSV0C018875

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CSV0C018875 

CSV0C018875 是一种基于喹啉的 EHMT2/G9a 抑制剂。 CSV0C018875 的细胞毒性低于 BIX-01294。

CSV0C018875

CSV0C018875 Chemical Structure

CAS No. : 442150-41-6

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生物活性

CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294[1].

IC50 & Target[1]

G9a

 

体外研究
(In Vitro)

CSV0C018875 (2.5-20 μM; 48 hours) inhibits the levels of H3K9me2 modifications in the histones[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 2.5 μM, 10 μM, 20 μM
Incubation Time: 48 hours
Result: Inhibited the enzymatic activity of G9a in a dose-dependent manner in HEK293 cells.

分子量

312.79

Formula

C18H17ClN2O

CAS 号

442150-41-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. M Ramya Chandar Charles, et al. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening. Biochimie. 2020 Jan;168:220-230.

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